Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137036 | 0.86 | ALOX5 (0.44) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8126095 | 0.84 | ACHE (0.48) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8116810 | 0.83 | CYP4F2 (0.49) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL8120463 | 0.83 | TTPA (0.48) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL9060281 | 0.75 | MAPT (0.49) | KMT2AMEN1MAPTTDP1ALOX5 | |
| SCHEMBL8118001 | 0.74 | HTT (0.50) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7843126 | 0.74 | PSEN1 (0.44) | KMT2AMEN1MAPTTDP1ALOX5 | |
| SCHEMBL11440561 | 0.74 | PSEN1 (0.44) | KMT2AMEN1MAPTTDP1ALOX5 | |
| SCHEMBL29670864 | 0.74 | PSEN1 (0.44) | KMT2AMEN1MAPTTDP1ALOX5 | |
| SCHEMBL11440558 | 0.74 | PSEN1 (0.44) | KMT2AMEN1MAPTTDP1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |