SCHEMBL8405207

SCHEMBL8405207

CCOC(=O)c1cc(F)c2c(c1Cl)C(=O)CCS2

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.38
ALDH1A1 P00352 4/20 0.38
LMNA P02545 3/20 0.38
MAPT P10636 3/20 0.38
HSD17B10 Q99714 2/20 0.38
NPC1 O15118 1/20 0.38
BAZ2B Q9UIF8 1/20 0.37
BAZ2A Q9UIF9 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 2/20 0.35
MAOB P27338 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CYP4F2 P78329 1/20 0.34
CYP4A11 Q02928 1/20 0.34
GAA P10253 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549364 0.88 ALDH1A1 (0.37) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8133195 0.88 LMNA (0.40) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL6732015 0.78 BAZ2B (0.41) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8404136 0.75 GAA (0.36) KDM4EALDH1A1MAPTHSD17B10BAZ2B
SCHEMBL8135012 0.75 BRD4 (0.41) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8549710 0.74 KDM4E (0.40) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8549713 0.74 KDM4E (0.40) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8136278 0.73 KDM4E (0.34) KDM4EALDH1A1HSD17B10HPGDKMT2A
SCHEMBL8544578 0.71 KDM4E (0.40) KDM4EALDH1A1LMNAMAPTHSD17B10
SCHEMBL8405209 0.70 MAOB (0.36) KDM4EALDH1A1LMNAMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863866-A HERBICIDES TO KILL WEEDS BUT NOT CROPS IDEMITSU KOSAN CO., LTD. (JP) 1999-01-26 US disclosed
EP-0819691-A1 PYRAZOLE DERIVATIVES IDEMITSU KOSAN COMPANY LIMITED (JP) 1998-01-21 EP disclosed