Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | WHR1 | P49842 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819852 | 0.79 | WHR1 (0.48) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7820197 | 0.77 | PDE4A (0.48) | KDM4EL3MBTL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL7825968 | 0.77 | WHR1 (0.46) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8884921 | 0.75 | KDM4E (0.48) | KDM4EL3MBTL1ALDH1A1HPGDHIF1A | |
| SCHEMBL7818387 | 0.74 | MAPT (0.46) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8886069 | 0.74 | WHR1 (0.43) | KDM4EL3MBTL1ALDH1A1HPGDHIF1A | |
| SCHEMBL8138601 | 0.73 | WHR1 (0.42) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8885954 | 0.72 | WHR1 (0.50) | L3MBTL1SMN1; SMN2TP53MAPTWHR1 | |
| SCHEMBL8131460 | 0.72 | PDE4A (0.42) | KDM4EL3MBTL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL8885068 | 0.72 | WHR1 (0.50) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634169-B1 | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5650410-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0634169-A1 | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |