Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | HTR2B | P41595 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539295 | 0.88 | HTR2C (0.57) | HTR2CHTR2BHTR2ACXCR1CXCR2 | |
| SCHEMBL14659637 | 0.78 | FAAH (0.50) | CXCR1CXCR2FAAHALDH1A1MAPT | |
| SCHEMBL590618 | 0.76 | KMT2A (0.61) | ALDH1A1MAPT | |
| SCHEMBL14659164 | 0.76 | ALDH1A1 (0.51) | CXCR1CXCR2FAAHALDH1A1MAPT | |
| SCHEMBL14659919 | 0.74 | ALDH1A1 (0.54) | FAAHALDH1A1MAPTRAD51 | |
| SCHEMBL241619 | 0.73 | NPC1 (0.63) | ALDH1A1MAPTRAD51NOTUM | |
| SCHEMBL30588272 | 0.73 | FAAH (0.50) | CXCR1CXCR2FAAHALDH1A1MAPT | |
| SCHEMBL7078078 | 0.72 | PORCN (0.56) | ALDH1A1MAPTRAD51ROCK2NOTUM | |
| SCHEMBL841457 | 0.72 | MAPT (0.56) | HTR2CHTR2BHTR2AALDH1A1MAPT | |
| SCHEMBL7337933 | 0.72 | TSHR (0.50) | ALDH1A1MAPTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984956-A1 | INDOLINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998052943-A1 | INDOLINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-26 | — | — | WO | disclosed |