Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8138713 | 1.00 | MAPK8 (0.40) | MAPK8MAPK9MAPK10KDM4CKDM4E | |
| SCHEMBL905751 | 0.89 | HTR2A (0.43) | MAPK8MAPK9MAPK10KDM4CNTRK1 | |
| Fumaric Acid SCHEMBL5990557 | 0.87 | NPSR1 (0.52) | KDM4EBLMNPSR1HTR2A | |
| Fumaric Acid SCHEMBL5990550 | 0.87 | NPSR1 (0.52) | KDM4EBLMNPSR1HTR2A | |
| Fumaric Acid SCHEMBL8146156 | 0.84 | HTR3A (0.40) | KDM4EHTR2ANAMPT | |
| Fumaric Acid SCHEMBL8146150 | 0.84 | HTR3A (0.40) | KDM4EHTR2ANAMPT | |
| Fumaric Acid SCHEMBL8138712 | 0.81 | MAPK8 (0.53) | MAPK8MAPK9MAPK10KDM4CKDM4E | |
| SCHEMBL5990554 | 0.78 | KDM4E (0.34) | KDM4EHTR2ANAMPT | |
| SCHEMBL9323969 | 0.76 | AKR1B1 (0.51) | MAPK8MAPK9MAPK10KDM4CNTRK1 | |
| SCHEMBL5989789 | 0.76 | HTR1A (0.43) | BLMNPSR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000012482-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |