Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.31 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.31 |
| ▸ | RORC | P51449 | 3/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8138799 | 1.00 | KDM4E (0.34) | KDM4ETSHRHSD17B10CAMK2DCSNK1A1 | |
| Fumaric Acid SCHEMBL8142605 | 0.94 | CSNK1A1 (0.32) | KDM4ETSHRHSD17B10CSNK1A1CSNK1D | |
| Fumaric Acid SCHEMBL8142601 | 0.94 | CSNK1A1 (0.32) | KDM4ETSHRHSD17B10CSNK1A1CSNK1D | |
| Fumaric Acid SCHEMBL8143969 | 0.91 | KDM4E (0.36) | KDM4ETSHRHSD17B10CAMK2DRORC | |
| Fumaric Acid SCHEMBL8143970 | 0.91 | KDM4E (0.36) | KDM4ETSHRHSD17B10CAMK2DRORC | |
| SCHEMBL8137244 | 0.91 | P2RX7 (0.34) | KDM4ETSHRHSD17B10CAMK2DCSNK1A1 | |
| Fumaric Acid SCHEMBL8136680 | 0.85 | RORC (0.35) | KDM4ETSHRHSD17B10RORCBTK | |
| Fumaric Acid SCHEMBL8136684 | 0.85 | RORC (0.35) | KDM4ETSHRHSD17B10RORCBTK | |
| Maleic Acid SCHEMBL8138730 | 0.84 | TEAD2 (0.40) | KDM4ETSHRHSD17B10KDM4CRORC | |
| Fumaric Acid SCHEMBL8138733 | 0.84 | TEAD2 (0.40) | KDM4ETSHRHSD17B10KDM4CRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594001-B1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0594001-A1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-27 | — | — | EP | disclosed |