Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 4/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303598 | 0.93 | P2RX7 (0.36) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| Fumaric Acid SCHEMBL8138796 | 0.91 | KDM4E (0.34) | P2RX7CAMK2DCSNK1A1CSNK1DCSNK1E | |
| Fumaric Acid SCHEMBL8138799 | 0.91 | KDM4E (0.34) | P2RX7CAMK2DCSNK1A1CSNK1DCSNK1E | |
| SCHEMBL9305694 | 0.89 | TDP1 (0.37) | P2RX7CAMK2DTDP1ESR1 | |
| SCHEMBL9305284 | 0.85 | CRHR1 (0.37) | — | |
| SCHEMBL9304250 | 0.84 | TDP1 (0.41) | CAMK2DTDP1MAOAMAOBACHE | |
| Fumaric Acid SCHEMBL8142605 | 0.84 | CSNK1A1 (0.32) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| Fumaric Acid SCHEMBL8142601 | 0.84 | CSNK1A1 (0.32) | P2RX7CSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| SCHEMBL9304005 | 0.82 | P2RX7 (0.38) | P2RX7MAPK1MAOACYP2D6 | |
| SCHEMBL8134789 | 0.81 | CRHR1 (0.37) | RPS6KA5HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594001-B1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2000-08-16 | — | — | EP | claimed |
| EP-0594001-A1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-27 | — | — | EP | claimed |
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |