Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508947 | 0.83 | NPC1 (0.46) | NPC1RAB9AUSP2TP53PKM | |
| SCHEMBL13165482 | 0.82 | KCNJ1 (0.52) | RAB9ASMN1; SMN2KCNJ1ALDH1A1NNMT | |
| SCHEMBL11637320 | 0.82 | NNMT (0.53) | NPC1RAB9AUSP2TP53PKM | |
| SCHEMBL1071097 | 0.79 | KCNJ1 (0.41) | USP2TP53PKMSMN1; SMN2KCNJ1 | |
| SCHEMBL4278637 | 0.76 | NPC1 (0.58) | NPC1RAB9AUSP2TP53PKM | |
| SCHEMBL17984648 | 0.74 | CYP1A2 (0.50) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL16571761 | 0.73 | NPC1 (0.40) | NPC1RAB9AUSP2TP53PKM | |
| SCHEMBL31058098 | 0.73 | KCNJ1 (0.46) | PKMKCNJ1ALDH1A1TSHRNNMT | |
| SCHEMBL4927935 | 0.71 | KCNJ1 (0.44) | NPC1RAB9ASMN1; SMN2KCNJ1GRM5 | |
| SCHEMBL21935846 | 0.71 | KCNJ1 (0.44) | NPC1RAB9AKCNJ1ALDH1A1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |
| EP-0989986-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | Abbott Laboratories (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998046605-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1998-10-22 | — | — | WO | disclosed |
| US-4145423-A | TREATMENT OF SCHISTOSOMIASIS AND AMOEBIASIS, NEMATODES, ANTIPROTAZOA | RHONE-POULENC INDUSTRIES (FR) | 1979-03-20 | — | — | US | disclosed |
| US-4104386-A | Derivatives of 1,2-dithiole and anti-bilharzia compositions thereof | RHONE-POULENC INDUSTRIES (FR) | 1978-08-01 | — | — | US | disclosed |