Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139286 | 0.83 | NPC1 (0.41) | NPC1RAB9APKMUSP2TP53 | |
| SCHEMBL11637320 | 0.82 | NNMT (0.53) | NPC1RAB9APKMUSP2TP53 | |
| SCHEMBL698657 | 0.79 | KDM4E (0.52) | TP53SMN1; SMN2KDM4EALDH1A1ALOX15 | |
| SCHEMBL4278637 | 0.76 | NPC1 (0.58) | NPC1RAB9APKMUSP2TP53 | |
| SCHEMBL27677649 | 0.76 | PIM2 (0.40) | PKMSMN1; SMN2KDM4EALDH1A1ALOX15 | |
| SCHEMBL11529735 | 0.75 | NPC1 (0.36) | NPC1RAB9APKMUSP2TP53 | |
| SCHEMBL17984648 | 0.74 | CYP1A2 (0.50) | NPC1RAB9ATP53SMN1; SMN2KDM4E | |
| Hydrazine SCHEMBL23496608 | 0.74 | KDM4E (0.48) | TP53SMN1; SMN2KDM4EALDH1A1ALOX15 | |
| SCHEMBL27506246 | 0.73 | PAX8 (0.36) | KDM4EALDH1A1L3MBTL1LMNAKMT2A | |
| SCHEMBL16571761 | 0.73 | NPC1 (0.40) | NPC1RAB9APKMUSP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145423-A | TREATMENT OF SCHISTOSOMIASIS AND AMOEBIASIS, NEMATODES, ANTIPROTAZOA | RHONE-POULENC INDUSTRIES (FR) | 1979-03-20 | — | — | US | disclosed |
| US-4144339-A | TREATMENT OF BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1979-03-13 | — | — | US | disclosed |
| US-4138487-A | NEMATOCIDES | RHONE-POULENC INDUSTRIES (FR) | 1979-02-06 | — | — | US | disclosed |
| US-4110450-A | BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1978-08-29 | — | — | US | disclosed |
| US-4104386-A | Derivatives of 1,2-dithiole and anti-bilharzia compositions thereof | RHONE-POULENC INDUSTRIES (FR) | 1978-08-01 | — | — | US | disclosed |