Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278531 | 0.79 | GBA1 (0.52) | GBA1HTR1APTGS2KMT2AAOC3 | |
| SCHEMBL8139286 | 0.79 | NPC1 (0.41) | KCNJ1MAPTPOLBGAAALDH1A1 | |
| SCHEMBL13165482 | 0.77 | KCNJ1 (0.52) | KCNJ1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL5133216 | 0.73 | NNMT (0.41) | ENPP2HTR1APTGS2MAPTKMT2A | |
| SCHEMBL11132196 | 0.72 | GBA1 (0.42) | GBA1HTR1APTGS2KMT2AAOC3 | |
| SCHEMBL14534850 | 0.71 | CRHR1 (0.43) | GBA1MAPTKMT2AMEN1MCL1 | |
| SCHEMBL25659249 | 0.71 | KCNJ1 (0.41) | KCNJ1KMT2AALDH1A1 | |
| SCHEMBL14534877 | 0.70 | HCAR3 (0.58) | KCNJ1GBA1MAPTKMT2AMEN1 | |
| SCHEMBL11637312 | 0.70 | HCAR3 (0.46) | ENPP2MAPTPOLBGAAAOC3 | |
| SCHEMBL31058098 | 0.69 | KCNJ1 (0.46) | KCNJ1MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039848-A1 | FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| US-20110039848-A1 | FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| US-20110039848-A1 | FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2272844-A1 | FIVE-MEMBERED RING COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039848-A1 | FIVE-MEMBERED RING COMPOUND | IL5, EPX, CCL11 | KCNJ1 986/4885GBA1 3482/4885ENPP2 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.