SCHEMBL8139519

SCHEMBL8139519

CC(C)(C)OC(=O)CNCc1ccc(CN)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPSAB1 Q15661 7/20 0.45
ANPEP P15144 1/20 0.44
ERAP2 Q6P179 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.44
PRSS1 P07477 3/20 0.41
TPSD1 Q9BZJ3 1/20 0.41
TPSG1 Q9NRR2 1/20 0.41
VSIR Q9H7M9 1/20 0.41
S1PR1 P21453 1/20 0.40
ATM Q13315 1/20 0.40
NR1H2 P55055 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
MAPT P10636 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8421187 0.86 VSIR (0.44) VSIRS1PR1ATMMAPTTDP1
SCHEMBL14205020 0.86 KMT2A (0.46) S1PR1ATMCYP2D6CYP2C9CYP2C19
SCHEMBL13662612 0.86 ATM (0.44) ANPEPERAP2VSIRS1PR1ATM
SCHEMBL15876277 0.86 MTNR1A (0.42) VSIRS1PR1ATMMAPTTDP1
SCHEMBL13605089 0.84 ANPEP (0.50) ANPEPERAP2CYP1A2CYP2C19GAA
SCHEMBL6140645 0.84 S1PR1 (0.40) VSIRS1PR1ATMMAPTTDP1
SCHEMBL14238298 0.84 PYCR1 (0.44) S1PR1ATMCYP1A2CYP2D6CYP2C19
SCHEMBL1227911 0.84 GAA (0.53) S1PR1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL1109881 0.84 S1PR1 (0.42) VSIRS1PR1ATMMAPTTDP1
SCHEMBL734928 0.84 ATM (0.55) ATMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114390-A AN ARGININAMIDE OR ORNITHINAMIDE COMPOUND AS TREATING MEMORY LOSS, MIGRAINE, SLEEP DISORDERS, PAIN, CARDIOVASCULAR DISEASES, SUBARACHNOIDAL BLEEDING, VASCULAR-HYPERTROPHIC CHANGES, CEREBRAL AND CORONARY VASOSPASMS KARL THOMAE GMBH (DE) 2000-09-05 US disclosed
EP-0885186-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-12-23 EP disclosed
WO-1997019911-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM DR. KARL THOMAE GMBH (DE) 1997-06-05 WO disclosed