Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21997499 | 0.95 | USP2 (0.35) | USP2ALDH1A1LMNACYP1A2TSHR | |
| SCHEMBL28595610 | 0.82 | HTR2C (0.32) | — | |
| SCHEMBL31031022 | 0.81 | ASGR1 (0.36) | — | |
| SCHEMBL23572515 | 0.79 | MEN1 (0.32) | ALDH1A1 | |
| SCHEMBL28585822 | 0.79 | NFKB1 (0.31) | — | |
| SCHEMBL23282418 | 0.78 | ASGR1 (0.40) | — | |
| SCHEMBL29085907 | 0.76 | — | — | |
| SCHEMBL23713791 | 0.76 | P2RX7 (0.30) | — | |
| SCHEMBL28587057 | 0.75 | DPP4 (0.34) | — | |
| SCHEMBL3361551 | 0.74 | LMNA (0.55) | USP2ALDH1A1LMNACYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057338-A | USEFUL IN THE TREATMENT OF DIABETES, CANCER, ACROMEGALY, RESTENOSIS, DEPRESSION, IRRITABLE BOWEL SYNDROME, PAIN AND DIABETIC RETINOPATHY | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |