Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138171 | 0.88 | GLP1R (0.34) | KMT2ARAB9ANPC1MEN1MAPK8 | |
| SCHEMBL8129351 | 0.84 | MAPT (0.32) | KMT2ARAB9ANPC1MEN1MAPK8 | |
| SCHEMBL8129487 | 0.83 | NPC1 (0.33) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL8129645 | 0.83 | HPGD (0.35) | KMT2ARAB9ANPC1MEN1MAPK8 | |
| SCHEMBL8135070 | 0.80 | MAPT (0.32) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL8143187 | 0.79 | MAPK8 (0.42) | KMT2ARAB9ANPC1MEN1MAPK8 | |
| SCHEMBL8144214 | 0.74 | NPSR1 (0.58) | KMT2ARAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8933479 | 0.71 | NPSR1 (0.53) | KMT2ARAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8128482 | 0.70 | ALDH1A1 (0.46) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL8129643 | 0.70 | ALDH1A1 (0.35) | KMT2ARAB9ANPC1MEN1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |