Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8933479 | 0.84 | NPSR1 (0.53) | ALDH1A1CYP1A2MAPTRAB9AMEN1 | |
| SCHEMBL8139117 | 0.82 | CDC7 (0.43) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL8137173 | 0.81 | NPSR1 (0.40) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL8144240 | 0.79 | NPC1 (0.37) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL8127687 | 0.77 | LMNA (0.41) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL8138184 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL2843820 | 0.76 | ALDH1A1 (0.59) | ALDH1A1CYP1A2MAPTRAB9ANPC1 | |
| SCHEMBL8144214 | 0.76 | NPSR1 (0.58) | ALDH1A1CYP1A2MAPTRAB9AMEN1 | |
| SCHEMBL8129645 | 0.76 | HPGD (0.35) | ALDH1A1MAPTRAB9ANPC1MEN1 | |
| SCHEMBL8129643 | 0.76 | ALDH1A1 (0.35) | ALDH1A1CYP1A2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0808318-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | Abbott Laboratories (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |