SCHEMBL8147355

SCHEMBL8147355

Nc1cc(C(F)(F)F)cc(Oc2ccc(C(F)(F)F)c(Oc3cc(C(F)(F)F)cc(N)c3C(F)(F)F)c2C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.38
RAB9A P51151 1/20 0.38
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.35
ATM Q13315 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
PTPN5 P54829 2/20 0.32
ALDH1A1 P00352 1/20 0.32
CFTR P13569 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8144277 0.81 MAPT (0.39) L3MBTL1MAPTNPSR1
SCHEMBL8152775 0.80 L3MBTL1 (0.42) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8150893 0.80 L3MBTL1 (0.36) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8145238 0.80 L3MBTL1 (0.43) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8143447 0.80 L3MBTL1 (0.47) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8150879 0.79 RAB9A (0.31) L3MBTL1RAB9A
SCHEMBL8137445 0.79 GLA (0.36)
SCHEMBL8145735 0.79 RAB9A (0.30) L3MBTL1RAB9A
SCHEMBL8152734 0.79 KDM4E (0.31) L3MBTL1RAB9AMAPT
SCHEMBL8146777 0.78 GAA (0.41) ATMNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed