Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154739 | 0.85 | KDM4E (0.55) | THRBTP53MTNR1A | |
| SCHEMBL8142612 | 0.83 | KDM4E (0.53) | MTNR1A | |
| SCHEMBL8149721 | 0.82 | THRB (0.65) | THRBTP53 | |
| SCHEMBL48652 | 0.81 | HRH3 (0.61) | — | |
| SCHEMBL29922137 | 0.81 | THRB (0.61) | THRBTP53 | |
| SCHEMBL16026529 | 0.81 | THRB (0.61) | THRBTP53 | |
| SCHEMBL14562256 | 0.79 | MTNR1A (0.58) | MTNR1A | |
| SCHEMBL8145351 | 0.79 | OGA (0.59) | THRB | |
| SCHEMBL12359541 | 0.78 | THRB (0.56) | THRBTP53 | |
| SCHEMBL8145641 | 0.78 | MTNR1A (0.46) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |