Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 9/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146420 | 0.87 | NR4A2 (0.55) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8140604 | 0.84 | RXRA (0.51) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8151850 | 0.84 | RXRA (0.51) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8152990 | 0.82 | CA2 (0.54) | PTGS2KMT2AMEN1POLB | |
| SCHEMBL8148454 | 0.81 | RXRA (0.51) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8172158 | 0.80 | NOX1 (0.52) | NOX1NR4A2MAPK14MAPK13MAPK12 | |
| SCHEMBL19700319 | 0.80 | NOX1 (0.52) | NOX1NR4A2MAPK14MAPK13MAPK12 | |
| SCHEMBL4651367 | 0.80 | NOX1 (0.52) | NOX1NR4A2MAPK14MAPK13MAPK12 | |
| SCHEMBL6964144 | 0.80 | NOX1 (0.52) | NOX1NR4A2MAPK14MAPK13MAPK12 | |
| SCHEMBL7502654 | 0.78 | PTGS2 (0.67) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090834-A | ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS | G.D. SEARLE & CO. (US) | 2000-07-18 | — | — | US | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |