Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150907 | 1.00 | KMT2A (0.38) | KMT2ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL8151811 | 0.93 | PKM (0.36) | KMT2ASMN1; SMN2PKML3MBTL1METAP2 | |
| SCHEMBL8151809 | 0.93 | PKM (0.36) | KMT2ASMN1; SMN2PKML3MBTL1METAP2 | |
| SCHEMBL8154437 | 0.91 | POLB (0.36) | KMT2ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL8154433 | 0.91 | POLB (0.36) | KMT2ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL8151051 | 0.90 | MAPT (0.36) | KMT2ASMN1; SMN2MAPTMEN1PKM | |
| SCHEMBL8151054 | 0.90 | MAPT (0.36) | KMT2ASMN1; SMN2MAPTMEN1PKM | |
| SCHEMBL8153420 | 0.88 | MEN1 (0.37) | KMT2ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL8153423 | 0.88 | MEN1 (0.37) | KMT2ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL8151629 | 0.86 | KMT2A (0.35) | KMT2ASMN1; SMN2GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |