Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | C1R | P00736 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151051 | 1.00 | MAPT (0.36) | MAPTPKMHTR6C1RPRSS1 | |
| SCHEMBL8150907 | 0.90 | KMT2A (0.38) | MAPTPKMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8150910 | 0.90 | KMT2A (0.38) | MAPTPKMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8153420 | 0.86 | MEN1 (0.37) | MAPTHTR6KMT2ASMN1; SMN2CTSS | |
| SCHEMBL8153423 | 0.86 | MEN1 (0.37) | MAPTHTR6KMT2ASMN1; SMN2CTSS | |
| SCHEMBL8151809 | 0.83 | PKM (0.36) | PKMHTR6KMT2ASMN1; SMN2 | |
| SCHEMBL8151811 | 0.83 | PKM (0.36) | PKMHTR6KMT2ASMN1; SMN2 | |
| SCHEMBL8151629 | 0.83 | KMT2A (0.35) | PKMKMT2ASMN1; SMN2 | |
| SCHEMBL8151627 | 0.83 | KMT2A (0.35) | PKMKMT2ASMN1; SMN2 | |
| SCHEMBL8154433 | 0.82 | POLB (0.36) | MAPTPKMKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |