Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151811 | 1.00 | PKM (0.36) | PKML3MBTL1METAP2CHEK1CDK8 | |
| SCHEMBL8150907 | 0.93 | KMT2A (0.38) | PKML3MBTL1METAP2SMN1; SMN2KMT2A | |
| SCHEMBL8150910 | 0.93 | KMT2A (0.38) | PKML3MBTL1METAP2SMN1; SMN2KMT2A | |
| SCHEMBL8154433 | 0.88 | POLB (0.36) | PKML3MBTL1SMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL8154437 | 0.88 | POLB (0.36) | PKML3MBTL1SMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL8151054 | 0.83 | MAPT (0.36) | PKMSMN1; SMN2KMT2AHTR6 | |
| SCHEMBL8151051 | 0.83 | MAPT (0.36) | PKMSMN1; SMN2KMT2AHTR6 | |
| SCHEMBL8153420 | 0.83 | MEN1 (0.37) | L3MBTL1SMN1; SMN2KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8153423 | 0.83 | MEN1 (0.37) | L3MBTL1SMN1; SMN2KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8151627 | 0.79 | KMT2A (0.35) | PKMSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |