Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153423 | 1.00 | MEN1 (0.37) | MEN1KMT2ACNR2L3MBTL1ALDH1A1 | |
| SCHEMBL8150910 | 0.88 | KMT2A (0.38) | MEN1KMT2ACNR2L3MBTL1ALDH1A1 | |
| SCHEMBL8150907 | 0.88 | KMT2A (0.38) | MEN1KMT2ACNR2L3MBTL1ALDH1A1 | |
| SCHEMBL8151054 | 0.86 | MAPT (0.36) | MEN1KMT2AMAPTSMN1; SMN2GBA1 | |
| SCHEMBL8151051 | 0.86 | MAPT (0.36) | MEN1KMT2AMAPTSMN1; SMN2GBA1 | |
| SCHEMBL8151809 | 0.83 | PKM (0.36) | KMT2AL3MBTL1HTTHSP90AA1SMN1; SMN2 | |
| SCHEMBL8151811 | 0.83 | PKM (0.36) | KMT2AL3MBTL1HTTHSP90AA1SMN1; SMN2 | |
| SCHEMBL8154433 | 0.80 | POLB (0.36) | MEN1KMT2AL3MBTL1ALDH1A1HTT | |
| SCHEMBL8154437 | 0.80 | POLB (0.36) | MEN1KMT2AL3MBTL1ALDH1A1HTT | |
| SCHEMBL8155942 | 0.80 | MEN1 (0.40) | MEN1KMT2ACNR2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |