Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20971224 | 0.69 | HCAR1 (0.45) | GAAL3MBTL1MGLLALDH1A1MAPT | |
| SCHEMBL29630826 | 0.69 | HCAR1 (0.45) | GAAL3MBTL1MGLLALDH1A1MAPT | |
| SCHEMBL22557832 | 0.67 | L3MBTL1 (0.46) | GAAL3MBTL1ALDH1A1MAPTMETAP2 | |
| SCHEMBL7981999 | 0.66 | GAA (0.58) | GAAMGLLALDH1A1MAPTMETAP2 | |
| SCHEMBL22729792 | 0.66 | HCAR1 (0.41) | GAAMGLLALDH1A1KDM4EHPGD | |
| SCHEMBL5605039 | 0.65 | GAA (0.49) | GAAMGLLALDH1A1MAPTHPGD | |
| SCHEMBL30671742 | 0.65 | GAA (0.49) | GAAMGLLALDH1A1MAPTHPGD | |
| SCHEMBL16461914 | 0.65 | MAPT (0.57) | GAAALDH1A1MAPTMETAP2KDM4E | |
| SCHEMBL3433008 | 0.65 | GAA (0.60) | GAAMGLLALDH1A1MAPTKDM4E | |
| SCHEMBL10904420 | 0.64 | GAA (0.47) | GAAL3MBTL1MGLLALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971921-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998039332-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-09-11 | — | — | WO | disclosed |