Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.74 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.74 |
| ▸ | GRM5 | P41594 | 6/20 | 0.70 |
| ▸ | PARP10 | Q53GL7 | 11/20 | 0.64 |
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.64 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154044 | 0.83 | DAPK3 (0.55) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL504652 | 0.82 | GRM5 (1.00) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL8167145 | 0.82 | PARP10 (0.76) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL16561672 | 0.82 | PARP10 (0.76) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL8151110 | 0.81 | PARP10 (0.78) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL8155836 | 0.79 | PARP10 (0.76) | GSK3BNTRK1FLT3GRM5PARP10 | |
| SCHEMBL12559528 | 0.79 | GRM5 (0.59) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL8156296 | 0.78 | PARP10 (1.00) | GSK3BCLK4GRM5PARP10PARP11 | |
| SCHEMBL8151102 | 0.78 | PARP10 (0.70) | GSK3BDAPK3NTRK1PIM1FLT3 | |
| SCHEMBL8155829 | 0.78 | PARP11 (0.68) | DAPK3PIM1CLK4GRM5PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |