Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155111 | 0.87 | ELANE (0.41) | MEN1KMT2AKCNJ11ELANENPC1 | |
| SCHEMBL8152609 | 0.86 | CTNNB1 (0.34) | KMT2AMAPTKDM4EHPGDHTT | |
| SCHEMBL8135372 | 0.86 | MEN1 (0.50) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL8155942 | 0.83 | MEN1 (0.40) | CNR2MEN1KMT2AMAPTGAA | |
| SCHEMBL8152068 | 0.83 | ALOX5 (0.41) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL8153984 | 0.82 | SMN1; SMN2 (0.35) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL8149948 | 0.81 | HPGD (0.34) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL8144738 | 0.79 | NPC1 (0.38) | CNR2MEN1KMT2AMAPTLMNA | |
| SCHEMBL8153420 | 0.76 | MEN1 (0.37) | CNR2MEN1KMT2AMAPTGAA | |
| SCHEMBL8153423 | 0.76 | MEN1 (0.37) | CNR2MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |