SCHEMBL8153278

SCHEMBL8153278

O=C(O)Oc1c(Cl)ccc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.47
LMNA P02545 5/20 0.43
NCEH1 Q6PIU2 1/20 0.43
WDR5 P61964 1/20 0.42
CYP1A2 P05177 2/20 0.41
LDHA P00338 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
TP53 P04637 2/20 0.40
NR4A1 P22736 1/20 0.40
NR4A2 P43354 1/20 0.40
NR4A3 Q92570 1/20 0.40
POLB P06746 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
HPGD P15428 2/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL269051 0.87 CYP2A6 (0.48) CYP2A6LMNANCEH1WDR5CYP1A2
SCHEMBL11417475 0.83 CYP2A6 (0.42) CYP2A6LMNANCEH1WDR5CYP1A2
SCHEMBL27556714 0.82 CYP1A2 (0.42) CYP2A6LMNANCEH1WDR5CYP1A2
SCHEMBL7538605 0.81 KMT2A (0.43) CYP2A6LMNAWDR5LDHANR4A2
SCHEMBL7068984 0.80 NCEH1 (0.45) LMNANCEH1WDR5LDHASMN1; SMN2
SCHEMBL8685474 0.80 HSD17B10 (0.50) WDR5CYP1A2LDHAPOLBHPGD
SCHEMBL398680 0.79 MEN1 (0.42) CYP2A6LMNANCEH1CYP1A2SMN1; SMN2
SCHEMBL11311995 0.79 ALDH1A1 (0.49) CYP2A6LMNANCEH1RAB9APOLB
SCHEMBL1416301 0.79 LMNA (0.41) CYP2A6LMNANCEH1CYP1A2SMN1; SMN2
SCHEMBL7942009 0.79 TSHR (0.47) CYP2A6NCEH1WDR5CYP1A2LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000012613-A9 FLAME RETARDANT POLYMER BLENDS, AND METHOD FOR MAKING GEN ELECTRIC (US) 2000-08-17 WO disclosed
WO-2000012613-A1 FLAME RETARDANT POLYMER BLENDS, AND METHOD FOR MAKING GENERAL ELECTRIC COMPANY (US) 2000-03-09 WO disclosed
EP-0892878-A1 REUSABLE CONCRETE FORM PANEL SHEETING Providence Industries, L.L.C. (US) 1999-01-27 EP disclosed
WO-1996032554-A1 REUSABLE CONCRETE FORM PANEL SHEETING PROVIDENCE INDUSTRIES, L.L.C. (US) 1996-10-17 WO disclosed
EP-0418377-A1 PROCESS FOR THE PREPARATION OF POLYCARBONATE AND/OR POLYARYLATE BLOCK COPOLYMERS WITH POLY(ARYL ETHERS) AMOCO CORPORATION (US) 1991-03-27 EP disclosed
EP-0406640-A2 Thermoplastic polycarbonate compositions having improved oxygen barrier properties GENERAL ELECTRIC COMPANY (US) 1991-01-09 EP disclosed
WO-1990012053-A1 PROCESS FOR THE PREPARATION OF POLYCARBONATE AND/OR POLYARYLATE BLOCK COPOLYMERS WITH POLY(ARYL ETHERS) AMOCO CORPORATION (US) 1990-10-18 WO disclosed
EP-0382800-A1 IMPACT MODIFIED POLYAMIDE/AROMATIC POLYCARBONATE BLENDS GENERAL ELECTRIC COMPANY (US) 1990-08-22 EP disclosed
WO-1990002156-A1 IMPACT MODIFIED POLYAMIDE/AROMATIC POLYCARBONATE BLENDS GENERAL ELECTRIC COMPANY (US) 1990-03-08 WO disclosed
EP-0320646-A2 Functionalized thermoplastic polymers GENERAL ELECTRIC COMPANY (US) 1989-06-21 EP disclosed
EP-0176008-A1 Aromatic polymers containing novel terminal groups GENERAL ELECTRIC COMPANY (US) 1986-04-02 EP disclosed
EP-0094585-A2 A process for making ordered ester/carbonate copolymers THE DOW CHEMICAL COMPANY (US) 1983-11-23 EP disclosed