Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ABL2 | P42684 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153287 | 1.00 | KDM4E (0.37) | KDM4EMAPTLMNAGPR35FBP1 | |
| SCHEMBL8151839 | 0.84 | KDM4C (0.38) | MAPTLMNAFBP1ABL1EGFR | |
| SCHEMBL8138769 | 0.70 | FBP1 (0.38) | MAPTLMNAFBP1ABL1EGFR | |
| SCHEMBL8138764 | 0.70 | FBP1 (0.38) | MAPTLMNAFBP1ABL1EGFR | |
| SCHEMBL8139015 | 0.68 | HTR3A (0.41) | KDM4EMAPTFBP1ABL1EGFR | |
| SCHEMBL8139013 | 0.68 | HTR3A (0.41) | KDM4EMAPTFBP1ABL1EGFR | |
| SCHEMBL905871 | 0.65 | HTR2A (0.43) | KDM4EMAPK8GABRA1GABRG2GABRB3 | |
| SCHEMBL6641843 | 0.65 | MTNR1A (0.37) | KDM4EMAPTLMNAFBP1ABL1 | |
| SCHEMBL6641840 | 0.65 | MTNR1A (0.37) | KDM4EMAPTLMNAFBP1ABL1 | |
| SCHEMBL1947929 | 0.65 | GABRA1 (0.53) | KDM4EMAPTLMNAGPR35FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000012482-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |