Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639218 | 0.84 | ALDH1A1 (0.47) | ALDH1A1PKMKMT2AAPEX1KDM4E | |
| SCHEMBL8166140 | 0.84 | TSHR (0.31) | — | |
| SCHEMBL14906997 | 0.76 | LMNA (0.31) | — | |
| SCHEMBL11640530 | 0.75 | ALDH1A1 (0.46) | ALDH1A1PKMKMT2AAPEX1KDM4E | |
| SCHEMBL418737 | 0.74 | AR (0.39) | ALDH1A1KDM4ESMN1; SMN2AR | |
| SCHEMBL11807016 | 0.74 | PTGS1 (0.41) | ALDH1A1PKMKMT2AKDM4EMEN1 | |
| SCHEMBL7217086 | 0.73 | GAA (0.38) | KMT2AALOX15MEN1SMN1; SMN2 | |
| SCHEMBL11801499 | 0.73 | PTGS1 (0.47) | ALDH1A1PKMKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8161475 | 0.72 | KMT2A (0.36) | ALDH1A1KMT2AMAPK1MEN1SMN1; SMN2 | |
| SCHEMBL11600810 | 0.72 | ALDH1A1 (0.41) | ALDH1A1PKMKMT2AAPEX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807267-B1 | CROSSLINKED POLYMERS CONTAINING URETHANE GROUPS | NOVARTIS AG (CH) | 2000-03-01 | — | — | EP | disclosed |
| US-5807927-A | POLYVINYL ACETALS MODIFIED BY ISOCYANATO ACRYLATES; CONTACT LENSES | CIBA VISION CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0807267-A1 | CROSSLINKED POLYMERS CONTAINING URETHANE GROUPS | Novartis AG (CH) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996024073-A1 | CROSSLINKED POLYMERS CONTAINING URETHANE GROUPS | NOVARTIS AG (CH) | 1996-08-08 | — | — | WO | disclosed |