SCHEMBL8154044

SCHEMBL8154044

C=C1NCCc2cc(-c3ccc(F)c(C)c3)ccc21

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DAPK3 O43293 1/20 0.55
NTRK1 P04629 1/20 0.55
PIM1 P11309 1/20 0.55
FLT3 P36888 1/20 0.55
GSK3B P49841 1/20 0.55
ROCK1 Q13464 1/20 0.55
CLK4 Q9HAZ1 1/20 0.55
GRM5 P41594 1/20 0.49
PARP10 Q53GL7 9/20 0.44
PARP11 Q9NR21 7/20 0.44
MPL P40238 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP11B2 P19099 1/20 0.36
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
PARP1 P09874 2/20 0.35
PTGS2 P35354 2/20 0.35
HSD17B1 P14061 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8163095 0.83 GSK3B (0.74) DAPK3NTRK1PIM1FLT3GSK3B
SCHEMBL18199094 0.75 PARP10 (0.54) GRM5PARP10PARP11CYP11B2PARP1
SCHEMBL8155750 0.72 PARP10 (0.72) PARP10PARP11MPLPARP1
SCHEMBL8167149 0.70 PARP10 (0.46) CLK4GRM5PARP10PARP11CYP3A4
SCHEMBL19142931 0.68 CASP1 (0.47) GRM5PARP10PARP11PARP1
SCHEMBL13760475 0.68 DRD2 (0.56) NTRK1PARP10PARP11PARP1
SCHEMBL13512608 0.68 PARP10 (0.64) PARP10PARP11CYP11B2PARP1
SCHEMBL23074494 0.68 PARP11 (0.43) PARP10PARP11PARP1
SCHEMBL18199057 0.68 PARP10 (0.40) PARP10PARP11PARP1
SCHEMBL8227734 0.68 METAP1 (0.49) GRM5CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008151184-A1 BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME VANDERBILT UNIVERSITY (US) 2008-12-11 WO disclosed