SCHEMBL8154435

SCHEMBL8154435

CC(CCCC(=O)O)(C(=O)O)P(=O)(O)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.44
MAPK1 P28482 1/20 0.44
ADRA1A P35348 1/20 0.44
HDAC4 P56524 1/20 0.44
SLC6A3 Q01959 1/20 0.44
HDAC1 Q13547 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
MAPT P10636 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
KEAP1 Q14145 1/20 0.39
NPSR1 Q6W5P4 1/20 0.38
FDPS P14324 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8159047 0.94 MAPT (0.46) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL8457132 0.91 KEAP1 (0.41) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL3380418 0.79 HDAC3 (0.50) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL8459394 0.79 FDPS (0.39) SMN1; SMN2FDPSFFAR1
SCHEMBL3382276 0.78 MAPT (0.50) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL8017479 0.74 FOLH1 (0.39) HDAC11FFAR1FOLH1
SCHEMBL8457120 0.73 ALDH1A1 (0.44) SMN1; SMN2FDPSHPGD
SCHEMBL8145004 0.73 FOLH1 (0.38) HDAC11FFAR1FOLH1
SCHEMBL10308636 0.72 HPGD (0.50) FDPSHPGD
SCHEMBL586261 0.70 SMN1; SMN2 (0.53) HDAC3MAPK1ADRA1AHDAC4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0957924-A4 CERTAIN PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARM INC (US) 2000-04-12 EP disclosed
EP-0957924-A1 CERTAIN PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1999-11-24 EP disclosed
WO-1997048399-A1 CERTAIN PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1997-12-24 WO disclosed