Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146828 | 0.90 | DRD2 (0.43) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL8149484 | 0.89 | TP53 (0.48) | ITKAURKATTKMAPTTP53 | |
| SCHEMBL5906012 | 0.86 | SMN1; SMN2 (0.41) | NPC1RAB9AKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL8149728 | 0.85 | ALDH1A1 (0.42) | KDM4EKMT2ADRD2SLC6A4GSK3B | |
| Hydrochloric Acid SCHEMBL8147037 | 0.83 | LMNA (0.39) | KDM4EDRD2GSK3BMAPTHTT | |
| SCHEMBL8151046 | 0.83 | HTR1D (0.40) | KDM4EDRD2MAPTALDH1A1HTR1A | |
| SCHEMBL5308040 | 0.83 | HTR1D (0.53) | ITKDRD2GSK3BHTR1A | |
| SCHEMBL5308907 | 0.82 | LRRK2 (0.47) | — | |
| SCHEMBL5311617 | 0.81 | CCR3 (0.38) | DRD2SMN1; SMN2CCR3 | |
| SCHEMBL5309292 | 0.81 | HTR1D (0.45) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000006173-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |