SCHEMBL8155472

SCHEMBL8155472

O=C1c2ccccc2C(=O)N1c1nc(Cl)nc(N2C(=O)c3ccccc3C2=O)n1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
ALPL P05186 4/20 0.54
AR P10275 2/20 0.46
ALDH1A1 P00352 3/20 0.46
HTT P42858 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.44
POLB P06746 1/20 0.43
CYP3A4 P08684 1/20 0.42
NFKB1 P19838 1/20 0.42
PMP22 Q01453 1/20 0.42
LMNA P02545 1/20 0.42
NPSR1 Q6W5P4 1/20 0.41
HSD17B10 Q99714 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10637058 0.96 ALPL (0.50) MEN1KMT2AALPLARALDH1A1
SCHEMBL8557706 0.89 MEN1 (0.54) MEN1KMT2AALPLARALDH1A1
SCHEMBL8555373 0.80 ALPL (0.46) MEN1KMT2AALPLARALDH1A1
SCHEMBL8733851 0.78 ALDH1A1 (0.50) MEN1KMT2AALPLARALDH1A1
SCHEMBL5322518 0.76 ALPL (0.44) MEN1KMT2AALPLARALDH1A1
SCHEMBL893875 0.74 MEN1 (0.44) MEN1KMT2AALPLARALDH1A1
SCHEMBL824432 0.73 ALDH1A1 (0.62) MEN1KMT2AALDH1A1HTTKDM4E
SCHEMBL29714525 0.72 POLB (0.59) MEN1KMT2AALPLALDH1A1HTT
SCHEMBL28663483 0.72 POLB (0.59) MEN1KMT2AALPLALDH1A1HTT
SCHEMBL12960613 0.72 MEN1 (0.35) MEN1KMT2AALDH1A1HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230403927-A1 AROMATIC COMPOUNDS UDC IRELAND LTD (IE) 2023-12-14 US disclosed
US-20230403927-A1 AROMATIC COMPOUNDS UDC IRELAND LTD (IE) 2023-12-14 US disclosed
US-11800787-B2 Metal complexes UDC IRELAND LIMITED (IE) 2023-10-24 US disclosed
US-11800787-B2 Metal complexes UDC IRELAND LIMITED (IE) 2023-10-24 US disclosed
EP-3160976-B1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2019-07-24 EP disclosed
US-20170141329-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2017-05-18 US disclosed
US-20170141329-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2017-05-18 US disclosed
WO-2016000803-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2016-01-07 WO disclosed
US-6013797-A CURING AGENT WHICH CROSSLINKS RESINS BY DECYCLIZATION WITHOUT RELEASING VOLATILE ORGANIC COMPOUNDS; FORMALDEHYDE-FREE CYTEC TECHNOLOGY CORP. (US) 2000-01-11 US disclosed
EP-0885214-A1 CYCLIC IMIDO-1,3,5-TRIAZINE CROSSLINKING AGENTS Cytec Technology Corp. (US) 1998-12-23 EP disclosed
US-5807929-A Cyclic imido-1,3,5-triazine crosslinking agents CYTEC TECHNOLOGY CORP. (US) 1998-09-15 US disclosed
WO-1997031914-A1 CYCLIC IMIDO-1,3,5-TRIAZINE CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1997-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230403927-A1 AROMATIC COMPOUNDS TYR, CTCF, MITF MEN1 2141/4885KMT2A 1055/4885ALPL 2580/4885
US-20170141329-A1 METAL COMPLEXES AP1M1, SOD1, AP3M1 MEN1 766/4885KMT2A 2648/4885ALPL 2574/4885
US-11800787-B2 Metal complexes AP1M1, SOD1, AP3M1 MEN1 766/4885KMT2A 2648/4885ALPL 2574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.