Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 5/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163015 | 0.84 | MAP3K9 (0.41) | MAP3K9MAP3K11PGRKDRCA1 | |
| Hydrochloric Acid SCHEMBL8157425 | 0.81 | MAP3K9 (0.41) | MAP3K9MAP3K11PGRKDRNTRK1 | |
| Hydrochloric Acid SCHEMBL8163953 | 0.80 | MAP3K9 (0.40) | MAP3K9MAP3K11PGRKDRNTRK1 | |
| Hydrochloric Acid SCHEMBL5345926 | 0.78 | MAP3K9 (0.41) | MAP3K9MAP3K11PGRKDRNTRK1 | |
| SCHEMBL8157431 | 0.75 | CA1 (0.36) | MAP3K9MAP3K11PGRKDRNTRK1 | |
| SCHEMBL8857148 | 0.74 | PNMT (0.43) | MAP3K9MAP3K11PGRKDRCA1 | |
| SCHEMBL29859431 | 0.74 | PNMT (0.43) | MAP3K9MAP3K11PGRKDRCA1 | |
| Hydrochloric Acid SCHEMBL7604176 | 0.74 | MAP3K9 (0.38) | MAP3K9MAP3K11PGRKDRNTRK1 | |
| SCHEMBL8163956 | 0.74 | MAP3K9 (0.35) | MAP3K9MAP3K11PGRCA1CA2 | |
| SCHEMBL8155678 | 0.74 | MAP3K9 (0.38) | MAP3K9MAP3K11PGRMAOANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716092-B1 | Organic transition metal compound and process for the preparation of polyolefin using same | TOSOH CORP (JP) | 2000-10-25 | — | — | EP | disclosed |
| US-5770666-A | METALLOCENE | TOSOH CORPORATION (JP) | 1998-06-23 | — | — | US | disclosed |
| EP-0716092-A1 | Organic transition metal compound and process for the preparation of polyolefin using same | TOSOH CORPORATION (JP) | 1996-06-12 | — | — | EP | disclosed |