Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | MAP3K9 | P80192 | 5/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857148 | 0.83 | PNMT (0.43) | MAP3K9MAP3K11PNMTPGRMAOA | |
| SCHEMBL29859431 | 0.83 | PNMT (0.43) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL9579948 | 0.81 | MAP3K9 (0.41) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL5358974 | 0.80 | PNMT (0.42) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL7251521 | 0.79 | MAP3K9 (0.41) | MAP3K9MAP3K11PNMTPGRMAOA | |
| SCHEMBL9841135 | 0.79 | PGR (0.40) | MAP3K9MAP3K11PNMTPGRMAOA | |
| SCHEMBL9579942 | 0.78 | PNMT (0.37) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL8155675 | 0.78 | MAP3K9 (0.40) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL5358545 | 0.78 | MAP3K9 (0.40) | MAP3K9MAP3K11PNMTPGRMAOA | |
| Hydrochloric Acid SCHEMBL5347494 | 0.78 | MAP3K9 (0.40) | MAP3K9MAP3K11PNMTPGRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230128-B2 | Organometallic fluorenyl compounds, preparations, and use | PHILLIPS POTROLEUM COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060122344-A1 | Organometallic Fluorenyl Compounds, Preparations, and Use | PHILLIPS PETROLEUM COMPANY (US) | 2006-06-08 | — | — | US | disclosed |
| EP-1304319-A2 | Metallocenes and processes therefor and therewith | Phillips Petroleum Company (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-0628566-B1 | Metallocenes and processes therefor and therewith | PHILLIPS PETROLEUM CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0628577-B2 | Silyl bridged metallocenes and use thereof | PHILLIPS PETROLEUM CO (US) | 2002-10-09 | — | — | EP | disclosed |
| US-6420579-B1 | SILYL, GERMANIUM OR TIN RADICALS WITH TITANIUM, ZIRCONIUM, HAFNIUM, VANADIUM, NIOBIUM AND TANTALUM METALS | PHILLIPS PETROLEUM COMPANY | 2002-07-16 | — | — | US | disclosed |
| US-6403734-B1 | POLYMERIZING ALPHA-OLEFIN BY CONTACTING WITH CATALYST SYSTEM COMPRISING BRIDGED FLUORENYL METALLOCENE CONTAINING METAL OF GROUP 4 OR 5 AND SUITABLE COCATALYST | PHILLIPS PETROLEUM COMPANY | 2002-06-11 | — | — | US | disclosed |
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0666267-B1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM CO (US) | 2001-04-18 | — | — | EP | disclosed |
| US-5451649-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0666267-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5436305-A | Preparing polymer catalysts by reaction of alkali metal alkyl and fluorenyl in solvent | PHILLIPS PETROLEUM COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5401817-A | Syndiotactic polypropylene | PHILLIPS PETROLEUM COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0628577-A2 | Silyl bridged metallocenes and use thereof | PHILLIPS PETROLEUM COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628566-A1 | Metallocenes and processes therefor and therewith | PHILLIPS PETROLEUM COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628565-A1 | Bis fluorenyl metallocenes and use thereof | PHILLIPS PETROLEUM COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0627440-A1 | 9-Substituted fluorenyl compounds and the preparation and use of metallocenes thereof | PHILLIPS PETROLEUM COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| CN-1068829-A | Organometallic fluorenyl compounds and preparation thereof and application | PHILLIPS PETROLEUM CO (US) | 1993-02-10 | — | — | CN | disclosed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122344-A1 | Organometallic Fluorenyl Compounds, Preparations, and Use | HMBS, FDPS, SOD1 | ACHE 440/4885MAP3K9 3601/4885MAP3K11 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.