Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306321 | 0.82 | HTR1A (0.47) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL6766552 | 0.80 | HTR1A (0.47) | ADRA1BHTR1A | |
| Oxalic Acid SCHEMBL8157336 | 0.79 | HTR1A (0.44) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL8306292 | 0.79 | HTR1A (0.47) | DRD2DRD3HTR1A | |
| SCHEMBL8305321 | 0.77 | ADRA1B (0.38) | DRD2DRD4DRD3ADRA1BHTR1A | |
| SCHEMBL8142921 | 0.75 | HTR1A (0.49) | ADRA1BHTR1AADRA1A | |
| Oxalic Acid SCHEMBL8153432 | 0.75 | HTR1A (0.44) | DRD2DRD4DRD3HTR1A | |
| Oxalic Acid SCHEMBL8148211 | 0.74 | FFAR4 (0.38) | DRD2DRD4DRD3ADRA1BHTR1A | |
| SCHEMBL8156185 | 0.72 | SIGMAR1 (0.35) | DRD3 | |
| SCHEMBL8145971 | 0.72 | ADRA1B (0.34) | DRD2DRD4DRD3ADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140331-A | FOR TREATING ANXIETY DISORDERS, DEPRESSION, PSYCHOSIS, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, ISCHAEMIC DISEASES, CARDIOVASCULAR DISORDERS, SIDE EFFECTS INDUCED BY CONVENTIONAL ANTIPSYCHOTIC AGENTS AND SENILE DEMENTIA | H. LUNDBECK A/S (DK) | 2000-10-31 | — | — | US | disclosed |