Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenoxylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.69 |
| ▸ | DRD4 | P21917 | 3/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.69 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.69 |
| ▸ | HTR2B | P41595 | 2/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | FPR1 | P21462 | 1/20 | 0.69 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.69 |
| ▸ | FPR2 | P25090 | 1/20 | 0.69 |
| ▸ | HTR1D | P28221 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loperamide SCHEMBL4876494 | 0.90 | OPRM1 (0.75) | OPRM1ADRA2ADRD4SLC6A4KCNA3 | |
| Loperamide SCHEMBL28086383 | 0.90 | OPRM1 (0.75) | OPRM1ADRA2ADRD4SLC6A4KCNA3 | |
| Diphenoxylate SCHEMBL1831278 | 0.85 | OPRM1 (0.51) | OPRM1ADRA2ADRD4SLC6A4KCNA3 | |
| Diphenoxylate SCHEMBL42124 | 0.84 | OPRM1 (0.98) | OPRM1SLC6A4KCNA3OPRD1OPRK1 | |
| Diphenoxylate SCHEMBL42940 | 0.83 | OPRM1 (1.00) | OPRM1SLC6A4KCNA3OPRD1OPRK1 | |
| Loperamide SCHEMBL8409268 | 0.83 | OPRM1 (1.00) | OPRM1ADRA2ADRD4SLC6A4MEN1 | |
| Loperamide SCHEMBL15048 | 0.83 | OPRM1 (1.00) | OPRM1ADRA2ADRD4SLC6A4MEN1 | |
| Loperamide SCHEMBL21327979 | 0.83 | OPRM1 (1.00) | OPRM1ADRA2ADRD4SLC6A4MEN1 | |
| Loperamide SCHEMBL9068543 | 0.83 | OPRM1 (1.00) | OPRM1ADRA2ADRD4SLC6A4MEN1 | |
| Loperamide SCHEMBL2346867 | 0.82 | OPRM1 (0.98) | OPRM1ADRA2ADRD4SLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156771-A | Method for alleviation of lower gastrointestinal disorders in a human patient | RUBIN WALTER (US) | 2000-12-05 | — | — | US | disclosed |