Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839832 | 0.80 | MAPT (0.49) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL10367148 | 0.80 | LMNA (0.49) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL8334018 | 0.80 | MAPT (0.49) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL12582119 | 0.77 | MAPT (0.67) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL7331424 | 0.77 | MAPT (0.49) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL8339624 | 0.76 | KDM4E (0.53) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL11550587 | 0.76 | MAPT (0.61) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL13875129 | 0.75 | MEN1 (0.62) | LMNAMAPTTDP1MEN1KMT2A | |
| SCHEMBL10373626 | 0.75 | MAPT (0.77) | LMNAMAPTALDH1A1MAPK1HTT | |
| SCHEMBL21243979 | 0.74 | ALDH1A1 (0.49) | LMNAMAPTALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000005206-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | disclosed |