Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | GFER | P55789 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11557311 | 0.81 | POLB (0.66) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL3625080 | 0.78 | MAPT (1.00) | MAPTGFERLMNAALDH1A1MAPK1 | |
| SCHEMBL5988811 | 0.77 | TP53 (0.53) | MAPTGFERLMNAALDH1A1HTT | |
| SCHEMBL14435697 | 0.77 | TP53 (0.48) | LMNAHTTTSHRTP53 | |
| SCHEMBL5258110 | 0.77 | SLC6A3 (0.45) | MAPTGFERALDH1A1MAPK1HTT | |
| SCHEMBL12295763 | 0.76 | ACHE (0.53) | MAPTALDH1A1MAPK1HTTKDM4E | |
| SCHEMBL8159508 | 0.76 | LMNA (0.53) | MAPTGFERLMNAALDH1A1MAPK1 | |
| SCHEMBL1048101 | 0.76 | MAPT (0.61) | MAPTGFERLMNAALDH1A1MAPK1 | |
| SCHEMBL2962631 | 0.74 | OPRM1 (0.55) | GFERLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL5744901 | 0.74 | MAPT (0.59) | MAPTGFERLMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140775-A | HYPOTENSIVE AGENTS | THE UPJOHN COMPANY (US) | 1979-02-20 | — | — | US | disclosed |