Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8159852 | 0.67 | ALDH1A1 (0.46) | MAPTALDH1A1NPSR1KDM4ENPC1 | |
| SCHEMBL7005313 | 0.64 | PKM (0.40) | MAPTALDH1A1NPSR1KDM4ENPC1 | |
| SCHEMBL2287559 | 0.64 | ALDH1A1 (0.58) | MAPTALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL7008865 | 0.64 | PIM1 (0.40) | LMNAL3MBTL1CCNT1PIM1CDK9 | |
| SCHEMBL2287568 | 0.64 | KDM4E (0.58) | MAPTALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL8577374 | 0.63 | CCNE2 (0.51) | AHRMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL6219061 | 0.62 | CHRM2 (0.53) | — | |
| SCHEMBL17178930 | 0.62 | KDM4E (0.57) | MAPTALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL7079795 | 0.61 | CCNE2 (0.62) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL29469528 | 0.61 | NTRK1 (0.58) | MAPTALDH1A1LMNANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032483-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 1999-07-01 | — | — | WO | disclosed |