Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 3/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169420 | 0.98 | ANPEP (0.47) | ANPEPCYP1A2MTNR1AMTNR1BCYP19A1 | |
| SCHEMBL20980078 | 0.79 | MTNR1A (0.35) | ANPEPMTNR1AMTNR1BCYP19A1SIGMAR1 | |
| SCHEMBL874650 | 0.75 | METAP1 (0.57) | CYP19A1METAP1SIGMAR1HTR1A | |
| SCHEMBL16335059 | 0.75 | ANPEP (0.49) | ANPEPHTR1APRCP | |
| SCHEMBL7932822 | 0.74 | HTR1A (0.52) | HTR1A | |
| SCHEMBL9685607 | 0.72 | FAAH (0.40) | FAAH | |
| SCHEMBL8173776 | 0.71 | ANPEP (0.47) | ANPEPCYP1A2MTNR1AMTNR1B | |
| SCHEMBL11773050 | 0.71 | HRH3 (0.39) | CYP19A1METAP1SIGMAR1HTR1APRCP | |
| SCHEMBL28790326 | 0.71 | CREBBP (0.44) | PRCP | |
| SCHEMBL10525748 | 0.70 | HTR1A (0.43) | HTR1APRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080752-A | FOR TREATING CONDITION WHICH REQUIRES ANTAGONISM OF A DOPAMINE RECEPTOR SUCH AS PSYCHTIC CONDITION | SMITHKLINE BEECHAM PLC (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0906284-A1 | TRICYCLIC AMINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047602-A1 | TRICYCLIC AMINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1997-12-18 | — | — | WO | disclosed |