Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 4/20 | 0.46 |
| ▸ | RXRG | P48443 | 3/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GCK | P35557 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27406198 | 0.90 | RXRA (0.49) | RXRAHCAR3PTGER1PTGER4PTGER3 | |
| SCHEMBL8163058 | 0.89 | RXRA (0.53) | RXRAPTGER1MRGPRX4 | |
| SCHEMBL1907786 | 0.89 | RXRA (0.53) | RXRAHCAR3PTGER1GCKALDH1A1 | |
| SCHEMBL8166970 | 0.87 | GCK (0.59) | RXRAHCAR3PTGER1PTGER4PTGER3 | |
| SCHEMBL6260236 | 0.85 | HCAR3 (0.51) | RXRAHCAR3 | |
| SCHEMBL8162472 | 0.85 | L3MBTL1 (0.42) | RXRAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL6261420 | 0.84 | HCAR3 (0.54) | RXRAHCAR3RXRBRXRG | |
| SCHEMBL8806684 | 0.84 | PTGER1 (0.57) | RXRAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL11566168 | 0.83 | HCAR3 (0.62) | RXRAHCAR3RXRBRXRGALDH1A1 | |
| SCHEMBL8703967 | 0.83 | CCR5 (0.48) | RXRAHCAR3PTGER1RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773930-B1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LTD (GB) | 2000-10-11 | — | — | EP | claimed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | claimed |
| WO-1996003380-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1996-02-08 | — | — | WO | claimed |
| US-5843942-A | Aromatic amino ethers as pain relieving agents | ZENECA LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |