Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.62 |
| ▸ | CA9 | Q16790 | 9/20 | 0.62 |
| ▸ | CA12 | O43570 | 8/20 | 0.62 |
| ▸ | CA1 | P00915 | 5/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181575 | 0.81 | ADRA1D (0.75) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8174151 | 0.79 | ADRA1D (0.72) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8174189 | 0.78 | ADRA1D (0.89) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8172876 | 0.77 | ADRA1B (0.80) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8174249 | 0.76 | ADRA1D (0.84) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8177368 | 0.73 | ADRA1D (1.00) | CA2CA9CA12CA1ADRA1D | |
| Hydrochloric Acid SCHEMBL8174041 | 0.72 | ADRA1D (0.87) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8174931 | 0.72 | ADRA1D (0.47) | CA2CA9CA12CA1ADRA1D | |
| SCHEMBL8173563 | 0.71 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BTP53POLB | |
| SCHEMBL8172981 | 0.68 | ADRA1D (0.83) | CA2CA9CA12CA1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | claimed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | claimed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | claimed |
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |