Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 5/20 | 0.54 |
| ▸ | ME1 | P48163 | 5/20 | 0.54 |
| ▸ | ME3 | Q16798 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8168851 | 0.86 | SLC6A7 (0.53) | ME2ME1ME3KDM4ESMN1; SMN2 | |
| SCHEMBL8163504 | 0.84 | PANK3 (0.48) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL3329378 | 0.82 | KDM4E (0.63) | ME2ME1ME3KDM4ESMN1; SMN2 | |
| SCHEMBL8168338 | 0.82 | SLC6A7 (0.55) | ME2ME1ME3KDM4ESMN1; SMN2 | |
| SCHEMBL8172191 | 0.81 | KDM4E (0.45) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL8168565 | 0.78 | HPGD (0.45) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL3333923 | 0.77 | KDM4E (0.62) | KDM4ESMN1; SMN2RBP4ALDH1A1MAPT | |
| SCHEMBL8921825 | 0.75 | HDAC1 (0.58) | SMN1; SMN2NPSR1 | |
| SCHEMBL23244396 | 0.74 | ME2 (0.86) | ME2ME1ME3KDM4EL3MBTL1 | |
| SCHEMBL12459920 | 0.72 | KDM4E (0.77) | ME2ME1ME3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112440-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | WO | disclosed |