Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334085 | 0.86 | KDM4E (0.53) | KDM4ESMN1; SMN2MALT1ALDH1A1 | |
| SCHEMBL8167199 | 0.81 | ME2 (0.54) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL8163504 | 0.75 | PANK3 (0.48) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL8168851 | 0.75 | SLC6A7 (0.53) | KDM4ESMN1; SMN2HPGDHSD17B10NPSR1 | |
| SCHEMBL3336642 | 0.74 | HSD17B10 (0.50) | KDM4ESMN1; SMN2HPGDHSD17B10NPSR1 | |
| SCHEMBL3334455 | 0.73 | TRPA1 (0.55) | KDM4ESMN1; SMN2HPGDHSD17B10NPSR1 | |
| SCHEMBL8168338 | 0.73 | SLC6A7 (0.55) | KDM4ESMN1; SMN2HPGDHSD17B10RBP4 | |
| SCHEMBL8170094 | 0.71 | KDM4E (0.40) | KDM4EHSD17B10MAPTHTT | |
| SCHEMBL3334079 | 0.71 | KDM4E (0.58) | KDM4ESMN1; SMN2HPGDHSD17B10NPSR1 | |
| SCHEMBL3334891 | 0.70 | KDM4E (0.53) | KDM4ESMN1; SMN2HPGDNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112440-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | WO | disclosed |