SCHEMBL8167266

SCHEMBL8167266

COc1ccc2c(c1)[CH]c1ccccc1-2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.50
CYP1A2 P05177 3/20 0.47
CYP2A6 P11509 2/20 0.47
SCN2A Q99250 1/20 0.46
ABL1 P00519 1/20 0.44
ABCB1 P08183 1/20 0.44
BCR P11274 1/20 0.44
CYP3A4 P08684 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A1 P04798 1/20 0.43
CYP2E1 P05181 1/20 0.43
CYP2C8 P10632 1/20 0.43
CYP4B1 P13584 1/20 0.43
CYP2B6 P20813 1/20 0.43
CYP3A5 P20815 1/20 0.43
CYP2A7 P20853 1/20 0.43
CYP3A7 P24462 1/20 0.43
CYP2F1 P24903 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7633767 0.89 CA1 (0.48) GPR3CYP1A2CYP2A6CYP3A4CYP2D6
SCHEMBL8162709 0.88 CYP1A2 (0.47) GPR3CYP1A2CYP2A6SCN2AABL1
SCHEMBL9205791 0.78 GPR3 (0.45) GPR3CYP1A2CYP2A6SCN2AABL1
SCHEMBL25693544 0.76 GPR3 (0.59) GPR3CYP1A2CYP2A6ABL1ABCB1
SCHEMBL27692616 0.76 CA1 (0.48) CYP1A2CYP2A6CYP3A4CYP2D6CYP2C9
SCHEMBL31669020 0.76 GPR3 (0.59) GPR3CYP1A2CYP2A6ABL1ABCB1
SCHEMBL2047998 0.72 ELANE (0.48) CYP1A2CYP2A6CYP3A4CYP2C19PDK2
SCHEMBL18426 0.72 ALDH1A1 (0.44) GPR3CYP1A2SCN2ACYP3A4CYP2D6
SCHEMBL3785422 0.72 SCN2A (0.54) GPR3CYP1A2CYP2A6SCN2AABL1
SCHEMBL5244835 0.72 TRPA1 (0.50) CYP1A2CYP2A6MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577581-B1 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY (US) 2000-07-05 EP claimed
US-5688735-A COORDINATION CATALYST FINA TECHNOLOGY, INC. (US) 1997-11-18 US disclosed