Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etofibrate SCHEMBL3122 | 1.00 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Etofibrate SCHEMBL29801484 | 1.00 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Etofibrate SCHEMBL1649349 | 0.99 | L3MBTL1 (0.54) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Ronifibrate SCHEMBL48852 | 0.96 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Simfibrate SCHEMBL5808862 | 0.96 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL10973734 | 0.92 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Picafibrate SCHEMBL2109083 | 0.85 | SMN1; SMN2 (0.65) | KMT2ALMNAALDH1A1MEN1USP2 | |
| Binifibrate SCHEMBL49116 | 0.85 | KMT2A (0.51) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Binifibrate SCHEMBL29388376 | 0.85 | KMT2A (0.51) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL2615470 | 0.84 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000069446-A1 | COMBINATION THERAPY FOR TREATING HYPERCHOLESTEROLEMIA | GELTEX PHARMACEUTICALS, INC. (US) | 2000-11-23 | — | — | WO | disclosed |
| EP-0971744-A2 | COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998040375-A2 | COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | disclosed |