Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Etofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etofibrate SCHEMBL8168409 | 0.99 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Etofibrate SCHEMBL29801484 | 0.99 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Etofibrate SCHEMBL3122 | 0.99 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Ronifibrate SCHEMBL48852 | 0.94 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Simfibrate SCHEMBL5808862 | 0.94 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL10973734 | 0.91 | L3MBTL1 (0.55) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Picafibrate SCHEMBL2109083 | 0.84 | SMN1; SMN2 (0.65) | KMT2ALMNAALDH1A1MEN1USP2 | |
| Binifibrate SCHEMBL49116 | 0.84 | KMT2A (0.51) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| Binifibrate SCHEMBL29388376 | 0.84 | KMT2A (0.51) | L3MBTL1KMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL2615470 | 0.83 | L3MBTL1 (0.59) | L3MBTL1KMT2ALMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| CN-1771034-A | Combinations of peroxisome proliferators-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor | PHARMACIA CORP (US) | 2006-05-10 | — | — | CN | disclosed |
| US-6264938-B1 | ADMINISTERING POLYDIALLYLAMINE AND HYDROXY-3-METHYLGLUTARYL/3-/, COENZYME A REDUCTASE | GELTEX PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |