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Serine

Serine

SCHEMBL8169168

CC[C@H](C)[C@H](N)C(=O)OC(=O)[C@@H]1CCCN1.N=C(N)NCCC[C@H](N)C(=O)OC(=O)CN.NCC(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1.N[C@@H](CO)C(=O)O

nearest known ligand 0.32

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Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 7/20 0.32
▸ NPY1R P25929 5/20 0.32
▸ NPY2R P49146 4/20 0.32
▸ NPY5R Q15761 4/20 0.32
▸ MAPK8 P45983 1/20 0.31
▸ MAPK9 P45984 1/20 0.31
▸ MAPK10 P53779 1/20 0.31
▸ SLC7A5 Q01650 1/20 0.30
▸ KDM1A O60341 1/20 0.30
▸ MAOB P27338 1/20 0.30
▸ KDM5A P29375 1/20 0.30
▸ KDM1B Q8NB78 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proline SCHEMBL9512840 0.92 NPY4R (0.31) NPY4RNPY1RNPY2RNPY5RMAPK8
Proline SCHEMBL3087442 0.89 MAPK8 (0.33) MAPK8MAPK9MAPK10KDM1AMAOB
Serine SCHEMBL9509964 0.88 NPY4R (0.38) NPY4RNPY1RNPY2RNPY5RSLC7A5
Arginine SCHEMBL18042248 0.83 NPY4R (0.33) NPY4RNPY1RNPY2RNPY5RSLC7A5
Glutamine SCHEMBL6546514 0.81 KDM1A (0.34) NPY4RNPY1RNPY2RNPY5RMAPK8
Aspartic Acid SCHEMBL9511966 0.80 MAPK8 (0.33) NPY4RNPY1RNPY2RNPY5RMAPK8
Leucine SCHEMBL7037614 0.80 PRCP (0.31) NPY4RNPY1RMAPK8MAPK9MAPK10
Serine SCHEMBL675717 0.80 NPY4R (0.39) NPY4RNPY1RNPY2RNPY5RSLC7A5
Serine SCHEMBL15752146 0.80 NPY4R (0.41) NPY4RNPY1RNPY2RNPY5RSLC7A5
SCHEMBL3044964 0.79 ITGB3 (0.37) SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278781-A2 Peptides with laminin activity THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1988-08-17 — — EP claimed
EP-1014945-A1 CATIONIC LIPID COMPOSITIONS TARGETING ANGIOGENIC ENDOTHELIAL CELLS The Regents of the University of California (US) 2000-07-05 — — EP disclosed
WO-1998040052-A9 CATIONIC LIPID COMPOSITIONS TARGETING ANGIOGENIC ENDOTHELIAL CELLS UNIV CALIFORNIA (US) 1999-09-02 — — WO disclosed
WO-1998040052-A1 CATIONIC LIPID COMPOSITIONS TARGETING ANGIOGENIC ENDOTHELIAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-09-17 — — WO disclosed