Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 7/20 | 0.33 |
| ▸ | NPY1R | P25929 | 5/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 4/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL18042258 | 0.95 | ITGB3 (0.34) | NPY4RNPY1RITGB3ITGA2BNPY2R | |
| Arginine SCHEMBL18042257 | 0.94 | NPY4R (0.34) | NPY4RNPY1RITGB3ITGA2BNPY2R | |
| Arginine SCHEMBL18042242 | 0.92 | NPY4R (0.37) | NPY4RNPY1RITGB3ITGA2BNPY2R | |
| Arginine SCHEMBL8614356 | 0.89 | KDM1A (0.33) | NPY4RNPY1RTHRBKDM1AMAOB | |
| Serine SCHEMBL8169168 | 0.83 | NPY4R (0.32) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Arginine SCHEMBL8843039 | 0.83 | THRB (0.38) | NPY4RNPY1RITGB3ITGA2BNPY2R | |
| Arginine SCHEMBL8613184 | 0.82 | KDM1A (0.33) | NPY4RNPY1RITGB3ITGA2BNPY2R | |
| Tyrosine SCHEMBL18042245 | 0.82 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Arginine SCHEMBL18042246 | 0.82 | TUBB4A (0.33) | GHSR | |
| Tyrosine SCHEMBL18042256 | 0.82 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338461-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2023-10-26 | — | — | US | disclosed |
| US-11696935-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2023-07-11 | — | — | US | disclosed |
| US-20210161992-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-06-03 | — | — | US | disclosed |
| US-20210069284-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-03-11 | — | — | US | disclosed |
| US-10881707-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2021-01-05 | — | — | US | disclosed |
| US-10842844-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2020-11-24 | — | — | US | disclosed |
| US-20180353566-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-12-13 | — | — | US | disclosed |
| US-20180280466-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-10-04 | — | — | US | disclosed |
| WO-2017094014-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2017-06-08 | — | — | WO | disclosed |
| US-20160256516-A1 | Phosphorylcholine Conjugates and Uses Thereof | TPCERA LTD. (IL) | 2016-09-08 | — | — | US | disclosed |