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Leucine

Leucine

SCHEMBL7037614

CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)OC(=O)[C@@H]1CCCN1.N[C@@H](CO)C(=O)O

nearest known ligand 0.31

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Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PRCP P42785 1/20 0.31
▸ NPY1R P25929 1/20 0.31
▸ NPY4R P50391 1/20 0.31
▸ MAPK8 P45983 1/20 0.31
▸ MAPK9 P45984 1/20 0.31
▸ MAPK10 P53779 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamine SCHEMBL5702894 0.96 KEAP1 (0.31) MAPK8MAPK9MAPK10
Leucine SCHEMBL5702941 0.92 MAPK8 (0.30) MAPK8MAPK9MAPK10
Glutamine SCHEMBL5702907 0.88 KDM1A (0.31) MAPK8MAPK9MAPK10
Arginine SCHEMBL1551248 0.86 PRCP (0.35) PRCPNPY1RNPY4RMAPK8MAPK9
Proline SCHEMBL6035442 0.85 NPY4R (0.34) PRCPNPY1RNPY4R
Leucine SCHEMBL11385380 0.82 CXCR4 (0.37) —
Arginine SCHEMBL4223569 0.82 PRCP (0.33) PRCPMAPK8MAPK9MAPK10
Arginine SCHEMBL23248653 0.82 PRCP (0.38) PRCPMAPK8MAPK9MAPK10
Arginine SCHEMBL11905093 0.82 PRCP (0.38) PRCPMAPK8MAPK9MAPK10
Arginine SCHEMBL14841994 0.82 PRCP (0.38) PRCPMAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1290032-A2 ANTIBODIES AGAINST PARTICULAR FORMS OF PROPSA AND USE THEREOF IN IMMUNOASSAYS Roche Diagnostics GmbH (DE) 2003-03-12 — — EP disclosed
WO-2001090194-A2 ANTIBODIES AGAINST PARTICULAR FORMS OF PROPSA AND USE THEREOF IN IMMUNOASSAYS ROCHE DIAGNOSTICS GMBH (DE) 2001-11-29 — — WO disclosed