Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170319 | 0.82 | MAPT (0.52) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL8170423 | 0.77 | FAAH (0.61) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL8172016 | 0.75 | ALDH1A1 (0.53) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL8163279 | 0.75 | MAPT (0.48) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL21353591 | 0.73 | — | — | |
| SCHEMBL29857922 | 0.73 | PLD1 (0.73) | MAPTMAPK1RAB9AALDH1A1KDM4E | |
| SCHEMBL15800694 | 0.73 | PLD1 (0.73) | MAPTMAPK1RAB9AALDH1A1KDM4E | |
| SCHEMBL8162517 | 0.72 | HTR1A (0.50) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL8168759 | 0.72 | HTR1A (0.50) | HTTMAPTNPC1LMNATP53 | |
| SCHEMBL8170400 | 0.72 | MAPT (0.45) | HTTMAPTNPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060472-A | Thiadiazole compounds useful as inhibitors of H+ /K+ atpase | APOTEX INC. (CA) | 2000-05-09 | — | — | US | claimed |
| WO-1999051584-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF H+/K+ ATPASE | APOTEX INC. (CA) | 1999-10-14 | — | — | WO | claimed |
| US-6060472-A | Thiadiazole compounds useful as inhibitors of H+ /K+ atpase | APOTEX INC. (CA) | 2000-05-09 | — | — | US | disclosed |
| WO-1999051584-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF H+/K+ ATPASE | APOTEX INC. (CA) | 1999-10-14 | — | — | WO | disclosed |